Tap into the innate adaptive responses to anemia due to chronic kidney disease (CKD)
Did you know the human body already has its own physiological process to help address anemia due to CKD?
Disruptions in oxygen sensing by the kidneys and dysregulation of hypoxia-inducible factor (HIF) activation, however, can blunt these innate adaptive responses and worsen anemia. In fact, it is estimated that 15% of all patients with CKD have anemia, with prevalence rising to approximately 85% when patients progress to dialysis.1-3
Patients with anemia due to CKD experience more than just fatigue; their condition is also associated with long-term poor clinical outcomes.4-8
Increased Risk of Cardiovascular Disease4
Rapid CKD Progression5
Reduced Quality of Life6
Vascular Access Complications7
Higher Rates of Mortality and Hospitalization5,8
Video
Burden of Anemia
Learn about the clinical burden of anemia due to CKD and how anemia can contribute to worsening of outcomes in patients with CKD.
Watch VideoAnemia due to CKD is more than just an erythropoietin and iron deficiency.1
Limited erythropoietin production and impaired iron metabolism can result from disrupted oxygen sensing by the kidneys. This underlying mechanism of anemia due to CKD dysregulates HIF activation, a cell signaling pathway that leads to the expression of genes to coordinate red blood cell production1,9
The HIF pathway is key to addressing the underlying mechanism and unlocking the innate adaptive responses to anemia9:
Stimulate endogenous erythropoietin production by renal erythropoietin-producing cells10
Enhance gastrointestinal iron uptake and mobilization from iron stores11
Facilitate erythroid progenitor maturation and proliferation12
Video
Pathogenesis of Anemia
Anemia due to CKD has a complex multifactorial pathogenesis. Recent scientific advancements in the therapeutic landscape of anemia due to CKD aim to address the underlying pathogenesis.
Watch VideoIt’s time to help the body help itself.
Enhance your knowledge about the HIF pathway and the scientific advancements in managing anemia due to CKD.
Connect With Our Medical Affairs TeamExplore the Complexities of Anemia Due to CKD
Anemia is a common complication of CKD and is a result of complex and multifactorial events that can contribute to poor clinical outcomes, such as cardiovascular events and mortality.1-8
Discover the Intricacies of the HIF Pathway
HIF activation is the body's physiological response to hypoxia. This pathway coordinates erythropoiesis in patients with anemia due to CKD by increasing endogenous production of erythropoietin and enhancing iron metabolism.1,9-12
Learn more about anemia due to CKD and the advancing science of the HIF pathway.
References
1. Portolés J, et al. Front Med (Lausanne). 2021;8:642296. 2. United States Renal Data System. 2023 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; Bethesda, MD; 2023. 3. Stauffer ME, Fan T. PLoS One. 2014;9(1):e84943. 4. Covic A, et al. Adv Ther. 2017;34:1662-1672. 5. Portolés J, et al. BMC Nephrol. 2013;14:2. 6. Eriksson D, et al. BMC Nephrol. 2016;17:97. 7. Locham SS, et al. J Vasc Surg. 2018;68(2):E11-E12. 8. Herzog CA, et al. J Card Fail. 2004;10:467-472. 9. Haase VH. Hemodial Int. 2017;21:S110-S214. 10. Wenger RH, et al. Am J Physiol Renal Physiol. 2010;298(6):F1287-F1296. 11. Mastrogiannaki M, et al. Blood. 2013;122(6):885-892. 12. Koury MJ, et al. Nat Rev Nephrol. 2015;11(7):394-410.